Kidney Disease Doesn't Just Affect the Kidneys — It Can Also Impact the Brain

Up to 70% of people on dialysis may experience cognitive impairment. Researchers are uncovering the biological links between kidney function and brain health.

Brain Geek News DeskJune 29, 2026Source: Nephrology and cognitive neuroscience
Chronic kidney disease is often associated with problems such as fatigue, high blood pressure, and the need for dialysis. But researchers are increasingly recognizing another, less visible consequence: its impact on the brain.
Recent studies suggest that up to 70% of people undergoing dialysis may experience some degree of cognitive impairment, ranging from difficulties with attention and memory to slower thinking and reduced executive function.
Scientists believe several factors may contribute to these changes. Reduced kidney function can allow waste products to accumulate in the blood, while chronic inflammation, vascular damage, anemia, and fluctuations in blood pressure during dialysis may all influence how well the brain functions.
The good news is that early detection, careful management of cardiovascular risk factors, physical activity, cognitive stimulation, and optimized medical care may help preserve cognitive health. Researchers are also working to better understand the biological links between kidney disease and the brain in order to develop new protective strategies.

Brain Geek Take

The brain doesn't work in isolation. Heart health, kidney function, metabolism, and blood circulation are all deeply connected. Protecting your overall health is one of the best ways to protect your cognitive abilities throughout life.
➡️ Related reading: The Complete Guide to the Human Brain and Brain Nutrition for Peak Performance on Brain Geek to explore how the health of your entire body influences brain function.

Suggested Reading

  • Lisa Mosconi — Brain Food
  • David Perlmutter — Grain Brain (note: some of his claims are debated and not consensus)

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